• Provision of signed and dated informed consent form

• Stated willingness to comply with all study procedures and availability for the duration of the study (up to 18 months: 6-month treatment plus 12-month follow up)

• Have a BMI ≥30 (or BMI ≥27 with a medical comorbidity) and BMI ≤50 kg/m2

• Have had laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy

• Suboptimal weight outcomes after MBS

• Be an otherwise healthy subject without uncontrolled medical problems, as determined by the study physician and medical co-investigators (physical examination, laboratory studies).

• Have had a physical in the past year

• Read, comprehend, and write English at a sufficient level to complete study-related materials.

• For females of reproductive potential: use of highly effective contraception and agreement to use such a method during study participation

• For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner