Reducing Exercise Intolerance Through Inspiratory Muscle Training in Obese Breast Cancer
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The investigators propose a randomized controlled trial to determine the effectiveness of inspiratory muscle training in improving exercise tolerance among stage 0-III obese breast cancer survivors.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:
• completed active treatment for a Stage 0-III breast cancer diagnosis within 6 months to 5 years of enrollment.
• obese as defined by a body mass index (BMI) of 30 to 50 kg/m2
• patients who are on adjuvant endocrine therapy will be allowed to participate.
• sedentary (participating in less than 90 min of moderate intensity activity per week) and have at least one limitation in activity on the 10-question RAND-36 Physical Function Subscale to ensure some exercise intolerance
Locations
United States
Ohio
The Ohio State University
RECRUITING
Columbus
Contact Information
Primary
Dharini M Bhammar, PhD
dharini.bhammar@osumc.edu
6143669467
Time Frame
Start Date: 2023-11-13
Estimated Completion Date: 2029-06-30
Participants
Target number of participants: 78
Treatments
Experimental: 4 wk IMT + 12 wk exercise
4 weeks of IMT, 3/week, 3 sets of 15 repetitions, intensity up to 70% of MIP using a pressure threshold device PLUS 12 weeks of aerobic exercise training including cycling, walking, elliptical, starting in week 5, 3/week, up to 50min per session, moderate intensity
Sham_comparator: 4 wk SHAM + 12 wk exercise
4 weeks of SHAM training, 3/week, 3 sets of 15 repetitions, intensity up of 10% of MIP using a pressure threshold device PLUS 12 weeks of aerobic exercise training including cycling, walking, elliptical, starting in week 5, 3/week, up to 50min per session, moderate intensity
Related Therapeutic Areas
Sponsors
Leads: Ohio State University Comprehensive Cancer Center