Elucidating the Interplay Between Circadian Rhythm and Physical Exercise on Metabolism in Patients With Type 1 Diabetes and Overweight
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in a variety of insulin sensitive organs. The aim of this project is to evaluate, by intervention, the interplay of circadian rhythm and high intensity interval training (HIIT) on glucose control and skeletal muscle metabolism in patients with overweight with or without type 1 diabetes (T1D).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:
• BMI 25-30
• type 1 diabetes or healthy subjects
Locations
Other Locations
Sweden
Ersta sjukhus
RECRUITING
Stockholm
Contact Information
Primary
Eva Toft, Assoc Prof
eva.toft@ki.se
+46 706722363
Backup
Veronica Qvisth, M.D.
veronica.qvist@erstadiakoni.se
+46 87146500
Time Frame
Start Date: 2022-05-18
Estimated Completion Date: 2026-10-31
Participants
Target number of participants: 50
Treatments
Active_comparator: Type 1 diabetes with overweight
High intensity interval training (HIIT), a single bout, randomly performed either in the morning or in the afternoon in a cross-over design.
Active_comparator: Overweight but otherwise healthy control subjects
High intensity interval training (HIIT), a single bout, randomly performed either in the morning or in the afternoon in a cross-over design.
Related Therapeutic Areas
Sponsors
Leads: Karolinska Institutet