he Role of Full-fat Dairy Products on Body Weight Control and Metabolic Health in Adults and Children

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of this research is to clarify the role of different dairy products including both full-fat and low-fat dairy in maintaining health in adults and children through its effects beyond their well-known contribution of healthy nutrients. The deleterious health consequences of obesity are recognized as a major financial burden to health care systems. Diets rich in fruits and vegetables and that also include dairy products have been suggested to play a role in the control of body weight and other aspects of health including the maintenance of healthy gut bacteria. In contrast, full-fat diets, especially those high in saturated fat, have been linked with negative health effects. Although dairy products represent an important source of saturated fat, it has been proposed that the combination of nutrients and complex food forms of the various dairy products may in fact counteract the negative effects of the fat. Thus, increased consumption of dairy products could very likely provide a partial dietary solution to improved body weight and metabolic health. Therefore, we are investigating the role of both full-fat and low-fat dairy products in their different physical forms (i.e. varying levels of fat that contribute to different textures) on appetite, food intake, control of blood sugar (glucose), body weight, cholesterol levels, and blood pressure in both children and adults. Existing dairy products (milk, cheese, and yogurt) ranging in fat content will be compared for their effects on satiety, food intake, glucose, insulin, satiety hormones, gut bacteria and other metabolic parameters linked to cardiometabolic health in normal weight children and adults, as well as in children and adults living with overweight and obesity.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 8
Maximum Age: 55
Healthy Volunteers: t
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⁃ Parent criteria are as follows:

• men and women between 18-55 years

• body mass index (BMI) between 30-40 kg/m2

• absence of pregnancy, breastfeeding or menopause (no menstruation)

• stable body weight (weight change \<5 kg for three months prior to screening).

⁃ Family criteria are as follows:

• being a family composed of at least one parent (mother/father) and at least two children between 8 to 16 years old (families between 3 to 5 persons). Families with at least one obese parent (BMI between 30-40 kg/m2) will be recruited since children coming from these families are more at risk of developing obesity and may benefit more from dairy products

• all participants should have no allergies to dairy products or lactose intolerance and be in good general health.

• since we are recruiting adults with obesity and dairy products may positively impact several metabolic markers, those with hypertension or deteriorated blood glucose and lipid profiles and/or taking medications will also be considered.

Locations
Other Locations
Canada
Laval University
RECRUITING
Québec
Contact Information
Primary
Lucie Brunelle, MSc, RD
lucie.brunelle@kin.ulaval.ca
4186562131
Backup
Shirin Panahi, PhD
spanahi329@gmail.com
4186562131
Time Frame
Start Date: 2021-06-19
Estimated Completion Date: 2024-08
Participants
Target number of participants: 300
Treatments
Active_comparator: Low-fat dairy products
Consumption of low-fat dairy products (4 servings/day with 2 servings/day coming from yogurt)
Active_comparator: Full-fat dairy products
Consumption of high-fat dairy products (4 servings/day with 2 servings/day coming from yogurt)
No_intervention: Control
Will be recommended to choose low-fat dairy products and alternatives based on recommendations from the 2007 Canadian Food Guide (2 servings/day for adults and 3-4 servings/day for children)
Related Therapeutic Areas
Sponsors
Leads: Laval University

This content was sourced from clinicaltrials.gov