Transpulmonary Pressure Guided Weaning From Invasive Mechanical Ventilation in Obese Patients With Respiratory Failure
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients spend on the ventilator. By decreasing the amount of time patients spend on the ventilator, they are less likely to develop complications such as infections, weakness or more procedures.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• on invasive mechanical ventilation for respiratory failure for \< 48 hours
• obese class II or higher (BMI greater than or equal to 35.0 kg/m2)
Locations
United States
Mississippi
University of Mississippi Medical Center
RECRUITING
Jackson
Contact Information
Primary
Meredith E Sloan, MD
mesloan@umc.edu
601-815-9634
Backup
Andrew Wilhelm, DO
awilhelm@umc.edu
601-984-5650
Time Frame
Start Date: 2022-04-11
Estimated Completion Date: 2025-04-30
Participants
Target number of participants: 128
Treatments
Experimental: Transpulmonary pressure guided positive end expiratory pressure
Patients in this group will have the positive end expiratory pressure on the ventilator set to a transpulmonary pressure of 0-2 cm H2O during ventilation and spontaneous breathing trials.
Active_comparator: Standard positive end expiratory pressure
Patients in this groups will have the positive end expiratory pressure on the ventilator set by the clinician during ventilation and set to a standard positive end expiratory pressure of 5-8 cm H2O during spontaneous breathing trials.
Related Therapeutic Areas
Sponsors
Leads: University of Mississippi Medical Center