Physiology of the Weight Reduced State
The goal of this clinical trial is to determine the physiological basis for the differences in weight regain among adults (25-59 years old) with obesity following participation in a behavioral weight loss program. Eligible participants will undergo a baseline evaluation after which they will enter an up to 20 week behavioral weight loss program with the goal of losing at least 7 percent of their baseline weight within 35 weeks. Participants who meet the weight loss goal will be asked to remain weight stable for 2 weeks after which they will undergo a clinical examination. They will then be observed for 1 year during which they will undergo 2 additional clinical examinations, one 4 months after completing the weight loss program, and the other 12 months after completing the weight loss program.
• Age: 25 - \<60 years
• BMI: 30 - \<40 kg/m2 at the first screening visit
• Within 5% of current weight, for the past 6 months at the first screening visit
• Able to participate in ergometry testing
• Has a smart phone, tablet or computer with access to the internet