Investigation of the Relationship Between Weight Loss Diet and Circadian Gene CLOCK 3111T/C Polymorphism

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Observational
SUMMARY

The goal of this observational study is to investigate the relationship of CLOCK 3111T/C (rs1801260) gene variant with nutritional habits, nutritional status, chronotype, sleep quality, some biochemical parameters in overweight or obese individuals and to observe its effect on weight loss diet intervention. The main questions it aims to answer are: * Is the frequency of carrying the CLOCK 3111T/C (rs1801260) gene risk allele different between individuals with normal body weight and those who are overweight or obese? * Do those with the CLOCK 3111T/C (rs1801260) risk allele have a higher frequency of evening chronotype and a shorter sleep duration? * Is the effect of CLOCK 3111T/C (rs1801260) gene alleles different on weight loss diet response in overweight or obese individuals? A questionnaire will be applied to the individuals in both groups (normal body weight and overweight/obese individuals) to evaluate their general characteristics, eating habits, adherence to Mediterranean diet, DASH and MIND. In addition, anthropometric measurements, 3-day food consumption record and 3-day physical activity record will be taken from individuals. CLOCK 3111T/C (rs1801260) gene variant analysis in whole blood, adiponectin and leptin hormones in serum samples will be studied. Participants those who are overweight/obese will be asked to follow a weight loss diet for 3 months. Researchers will compare participants with normal body weight and those who are overweight or obese to see if there is a difference between the frequency of carrying the CLOCK 3111T/C (rs1801260) gene risk allele.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 50
Healthy Volunteers: t
View:

• Be in the 20-50 age range

• BMI in the range of 25-40 kg/m2 for the study group

• BMI of 18.5-24.9 kg/m2 for the control group

Locations
Other Locations
Turkey
Hacettepe University
RECRUITING
Ankara
Contact Information
Primary
Hande Gül Ulusoy Gezer, MSc
handegululusoy@hacettepe.edu.tr
+905357314604
Time Frame
Start Date: 2023-02-20
Estimated Completion Date: 2026-02-01
Participants
Target number of participants: 400
Treatments
Study group
Age range 20-50, BMI range of 25-40 kg/m2
Control group
Age range 20-50, BMI range18.5-24.9 kg/m2
Related Therapeutic Areas
Sponsors
Leads: Hacettepe University

This content was sourced from clinicaltrials.gov