Examining the Optimal Exercise Frequency for Alleviating Liver Fat in Centrally Obese Adults With Non-Alcoholic Fatty Liver Disease (NAFLD): A Comparative Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to examine the comparative effectiveness of different exercise frequencies (once-a-week vs. thrice-a-week) for reducing liver fat in centrally obese adults with non-alcoholic fatty liver disease (NAFLD), with weekly exercise volumes aligned with the World Health Organization's physical activity recommendations.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 69
Healthy Volunteers: f
View:
• Cantonese, Mandarin, or English speaking Chinese;
• Aged 18-69;
• Male or female;
• Centrally obese according to the Asian-specific cut-off (waist circumference ≥90 cm for males; ≥80 cm for females) and with BMI ≥23;
• With NAFLD (defined as \>5% intrahepatic triglycerides assessed by 1H-MRS);
• Willing to participate in exercise training to improve NAFLD.
Locations
Other Locations
Hong Kong Special Administrative Region
LKS Faculty of Medicine
RECRUITING
Hong Kong
Contact Information
Primary
Parco M. Siu, PhD
pmsiu@hku.hk
2831 5262
Time Frame
Start Date: 2023-03-02
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 300
Treatments
Experimental: Once-a-week Exercise
Once-a-week vigorous-intensity exercise for 4 months.
Experimental: Thrice-a-week Exercise
Thrice-a-week vigorous-intensity exercise for 4 months.
Other: Usual Care Control
Bi-weekly health education for 4 months.
Related Therapeutic Areas
Sponsors
Leads: The University of Hong Kong