Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 80
Healthy Volunteers: t
View:
• U.S. Veteran
• Self-reported COVID-19 naïve or COVID-19 \> 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom \>4 weeks)
• Body Mass Index: 19-25 or 30-50 kg/m2
Locations
United States
Maryland
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
RECRUITING
Baltimore
Texas
South Texas Health Care System, San Antonio, TX
RECRUITING
San Antonio
Contact Information
Primary
Kristina Marcus, MS
kristina.marcus@va.gov
(410) 605-7000
Time Frame
Start Date: 2024-06-03
Estimated Completion Date: 2028-09-30
Participants
Target number of participants: 150
Treatments
Experimental: Weight Loss
Participants will be asked to participate in a 1x/week center-based or tele-health nutrition diet class, 2x/week center-based exercise classes, and 1x/week exercise session conducted on their own for approximately 12 weeks.
Active_comparator: Weight Stability
Participants will be asked to participate in a 1x/week center-based or tele-health education class, 2x/week center-based or tele-health stretching/balance classes, and 1x/week stretching/balance session conducted on their own for approximately 12 weeks.
Sponsors
Leads: VA Office of Research and Development
Collaborators: South Texas Veterans Health Care System, Baltimore VA Medical Center