Mechanistic Studies in Human Subcutaneous Adipose Tissue
The investigator recently showed that the glycan-binding adipokine galectin-1 increased during overfeeding and that galectin-1 independently could predict type 2 diabetes. Further, the molecules that induce insulin release in the fasting state when blood glucose is normal remain elusive. It is possible that galectin-1 is involved in adaptive mechanisms in adipose tissue in obese subjects.
• Men and women of age: 40.0 - 70.0 years
• BMI: 18.0 - 25.0 kg/m2 (lean subjects) and BMI 30.0 - 38.0 kg/m2 (Ob-IS and Ob-IR)
• Fasting insulin \< 9.0 mU/l (lean and Ob-IS subjects) and fasting insulin \> 9.0 mU/l (Ob-IR)
• Fasting glucose \< 6.1 mmol/l
• Body temperature \< 37.5°C
• First-degree relative with known T2D in Ob-IR
• Weight stable ± 5 kg \< 3 months before screening
• Fluent in Swedish and can follow given instructions
• Consent given to participate