The Effect of Timed-Restricted Eating on Insulin Sensitivity, De Novo Lipogenesis and Liver Fat in Subjects With Obesity and Insulin Resistance
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin resistance.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 75
Healthy Volunteers: t
View:
• Ability to provide informed consent;
• BMI \> 30kg/m\^2;
• Insulin resistance, as defined by fasting plasma insulin \> 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose \> 5.3 and \< 7.0 mmol/L;
• Stable weight for 3 months prior to study inclusion
• For women, 1 year after last menstrual cycle
Locations
Other Locations
Netherlands
Amsterdam UMC, location AMC
RECRUITING
Amsterdam
Contact Information
Primary
Jur Kroon, BSc
jur.kroon@amsterdamumc.nl
+31 683238752
Backup
Sarah E Siegelaar, MD PhD
s.e.siegelaar@amsterdamumc.nl
Time Frame
Start Date: 2023-10
Estimated Completion Date: 2027-12
Participants
Target number of participants: 30
Treatments
Experimental: Early time-restricted eating
* 50% of daily calories at breakfast, 35% at lunch and 15% at dinner. 85% of calories consumed in 6h, i.e., between 7AM and 1PM.~* Eating period, 10h (7AM-5PM); fasting period, 14h; Breakfast between 7 and 8 AM; lunch between 12 AM and 1 PM; dinner between 4 and 5 PM.
Experimental: Late time-restricted eating
* 15% of daily calories at breakfast, 35% at lunch and 50% at dinner. 85% of calories consumed in 6h, i.e., between 2PM and 8PM.~* Eating period, 10h (10AM-8PM), fasting period, 14h; Breakfast between 10 and 11 AM; lunch between 2 and 3 PM; dinner between 7 and 8 PM.
Related Therapeutic Areas
Sponsors
Collaborators: Diabetesfonds
Leads: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)