The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents (FAME)

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity. The investigators will assess the following hypotheses: * Weight condition is reflected by the fecal metabolome (WP1) * Emotional stress is implicated in weight condition (WP1) * Functionality of the gut microbiome is related to the diet-stress-obesity axis (WP2) * Dietary pattern impacts the fecal metabolome and gut microbiome (WP2) * Personalized dietary intervention outperforms generalized dietary approaches (WP3) Participants will: * Produce a saliva, stool and hair sample * Fill in questionnaires regarding mental health, medical health and demographic information * Fill in a food frequency questionnaire and a 24-hrecalls * Be measured (height, weight, fat% and waist circumference) The samples will be analyzed using a technique called metabolomics to identify biomarker candidates with diagnostic and/or prognostic potential. Additionally, microbiome analysis will be performed to map the microbiome of all groups.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 11
Maximum Age: 17
Healthy Volunteers: t
View:

• Age 11-17 years

Locations
Other Locations
Belgium
UZ Antwerpen
RECRUITING
Antwerp
ZNA Middelheim
RECRUITING
Antwerp
Zeepreventorium
RECRUITING
De Haan
AZ Jan Palfijn Gent, Oost-Vlaanderen, Belgium, 9000
RECRUITING
Ghent
Ghent University Hospital
RECRUITING
Ghent
Clairs Vallons
RECRUITING
Ottignies-louvain-la-neuve
AZ Delta
RECRUITING
Roeselare
Contact Information
Primary
Emile Callemeyn, Dr
emile.callemeyn@ugent.be
+32473271636
Backup
Lynn Vanhaecke, Prof
Lynn.Vanhaecke@ugent.be
0032 9 264 74 57
Time Frame
Start Date: 2022-01-11
Estimated Completion Date: 2027-07
Participants
Target number of participants: 750
Treatments
Overweight/obese
BMI-Z \> 25
Normal weight
BMI-Z \< 25
Related Therapeutic Areas
Sponsors
Leads: University Ghent

This content was sourced from clinicaltrials.gov