Evaluation of the Effects of Tomato Consumption on the Parameters of Hepatic Steatosis, Intestinal Function and on Glucose and Lipid Metabolism in Subjects With NAFLD

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The study in question is an interventional study with nutritional intervention. the aim of the study is to evaluate whether a diet enriched with tomatoes can have favorable effects on: * specific aspects associated with NAFLD, such as the degree of hepatic steatosis and fibrosis; * circulating levels of molecules correlated with the degree of generalized and hepatic inflammation and the blood concentrations of metabolic and cardiovascular risk factors associated with abdominal obesity; * intestinal barrier; * body composition; * intestinal microbiota; * symptoms of IBS (irritable bowel syndrome) in patients with NAFLD.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: t
View:

• Patients with BMI≤30;

• Diagnosis of hepatic steatosis, formulated on the basis of criteria

Locations
Other Locations
Italy
Irccs Saverio de Bellis
RECRUITING
Castellana Grotte
Contact Information
Primary
Giovanni De Pergola, MD
giovanni.depergola@irccsdebellis.it
0804994653
Time Frame
Start Date: 2024-05-14
Estimated Completion Date: 2025-05-20
Participants
Target number of participants: 60
Treatments
Experimental: Case Group - Tomato-free diet
Subjects assigned to this arm will follow a tomato-free diet
Experimental: Case group - Diet enriched with tomatoes
Subjects assigned to this group will follow a diet with pre-established quantities of tomato and sauce
Sponsors
Collaborators: Dr. Cici Rosalisa, Dr. Pesole Pasqua Letizia, Dr. Pinto Giuliano, Dr. Russo Francesco, Dr. Ignazzi Antonia, Dr. Riezzo Giuseppe, Dr. Tatoli Rossella, Dr. Zappimbulso Marianna, Dr. Shahini Endrit, Dr. Cerabino Nicole, Dr. Giannuzzi Vito, Dr. Cozzolongo Raffaele, Dr. Coletta Sergio, Dr. Martina Di Chito, Dr. Donghia Rossella, Dr. Ancona Anna, Dr. Stabile Dolores, Dr. Donvito Rosanna, Dr. Cesternino Anna Maria, Dr. Notarnicola Maria, Dr. D'Attoma Benedetta, Dr. De Nunzio Valentina, Dr. Di Stasi Vincenza
Leads: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

This content was sourced from clinicaltrials.gov

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