Impact of the Incretin System on Brain Insulin Sensitivity in Humans with Normal Weight, Overweight and Obesity
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The overarching goal of the current study is to investigate the effect of GLP-1 on brain insulin responsiveness in a randomized, single-blinded, within subject cross-over study design. To this end, investigators will compare the effect of the administration of semaglutide versus placebo, followed by an fMRI with administration of intranasal insulin or placebo.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:
• BMI between 18.5 and 24.9 kg/m2; and between 27.5 kg/m2 and 40 kg/m2
• Written consent to participate in the study
• Written consent to be informed about incidental findings
Locations
Other Locations
Germany
University Clinic Tubingen, Department of Internal Medicine IV
RECRUITING
Tübingen
Contact Information
Primary
Stephanie Kullmann, PhD
stephanie.kullmann@med.uni-tuebingen.de
0049707129
Time Frame
Start Date: 2024-07-01
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 60
Treatments
Experimental: GLP-1
Acute administration of 0.25 mg semaglutide (0.19 ml)
Placebo_comparator: Placebo
Acute administration of 0.19 ml NaCl
Related Therapeutic Areas
Sponsors
Leads: University Hospital Tuebingen