Extracellular Vesicles, Insulin Action, and Exercise on Vascular Function in Type 2 Diabetes
Extracellular vesicles (EVs) play a role in obesity-induced insulin resistance and likely impact the development of cardiovascular disease. However, little is known on how EVs affect vascular insulin action in people. The purpose of this study is to understand how EVs play a role in type 2 diabetes related cardiovascular disease. This research will also study if exercise can change how EVs impact blood flow and metabolic health. This study will contribute to designing precision medicine to treat/prevent cardiovascular disease in type 2 diabetes.
• Male or female 30 - 80 years old.
• HbA1c \<5.7% and fasting glucose \<100mg/dl to be considered NGT
• T2D diagnosis or confirmation HbA1c ≥6.5% and fasting glucose ≥126 mg/dl
• Prescribed metformin, GLP-1 agonists (oral/injectable), TZDs, DPP-IV inhibitors, Acarbose, SGLT-2 inhibitors ≥1 year.
• Has a body mass index of 20-25 or 28-45 kg/m2.
• Not diagnosed with Type 1 diabetes.
• Not currently engaged in \>150 min/wk of exercise.