The Metabolic Effects of the Exercise-metabolite N-lactoyl-phenylalanine (Lac-Phe)
The goal of this double-blinded, randomized cross-over clinical trial is to assess the isolated (i.e. outside the context of exercise) effects of Lac-Phe on appetite and glucose concentrations in healthy volunteers with obesity (BMI 28-35). The main questions it aims to answer are: * Does Lac-Phe reduce appetite in humans? * Does Lac-Phe have glucose-lowering properties in humans? During the study, participants will: * receive an intravenous infusion of Lac-Phe on one study day and a NaCl infusion on another study day. * drink a standard mixed meal * eat an ad libitum meal test * answer appetite questionnaires * indirect calorimetry * blood samples for hormone and substate analyses
• A body mass index (BMI) between 28-35 kg/m2
• Older than 18 years of age
• Hgb within a normal range (females: 7.3-9.5 mmol/L, males: 8.3-10.5 mmol/L)
• Females can be included if they are either postmenopausal or actively use hormonal contraception (e.g., oral contraceptive pill or hormone-releasing intrauterine device).