Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation. There is little information about the metabolic changes that lead to the rapid onset obesity in these children. The investigators would like to study the metabolic phenotype of these children to understand the disturbances in energy balance that lead to the rapid onset obesity.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 2
Maximum Age: 20
Healthy Volunteers: f
View:
• Children with ROHHAD syndrome
Locations
United States
New York
Boston Children's Hospital
COMPLETED
Boston
Columbia University Irving Medical Center
RECRUITING
New York
Contact Information
Primary
Vidhu Thaker, MD
vvt2114@cumc.columbia.edu
2128515315
Time Frame
Start Date: 2015-11
Estimated Completion Date: 2025-12
Participants
Target number of participants: 12
Treatments
Cases of ROHHAD syndrome
Children diagnosed with ROHHAD syndrome during the course of their clinical care by their physicians.~The investigators will perform transcriptome profiling in this group.
Control cohort
Unaffected first degree family members. The investigators will perform transcriptome profiling in this group.
Authors
Related Therapeutic Areas
Sponsors
Leads: Columbia University