Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?
The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand: 1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison? 2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?
• Signed Informed Consent Form
• Age between 18 and 60 years
• BMI 30-50 kg/m2
• Knowledge of German, which requires sufficient written and allow oral patient education
• Blood pressure \< 140/90 mmHg
• Normal glucose metabolism
‣ HbA1c \< 6.5 %
⁃ Fasting Glucose \< 7.0 mmol/l
• Normal lipid metabolism
• o LDL-cholesterol \< 5.0 mmol/l
• ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference)
• TG \> 1.7 mmol/l
• HDL-cholesterol \> 1.0 mmol/l (male) / \> 1.3 mmol/l (female)
• Fasting glucose ≥ 5.6 mmol/l
• BP ≥ 130/85 mmHg