Oxygenation Procedure for Obese Patients Using High Flow Oxygen Therapy Combined With Non-invasive Ventilation During Intubation in the Operating Room: a Randomised Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during apnoea. Complications associated with induction and intubation in the operating room are more frequent in obese patients. Preoxygenation is a cornerstone in the management of patients at risk of desaturation during induction. The study aims to compare two oxygenation strategies , in obese patients. Oxygenation using a combination of NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen) compared with NIV alone in the operating room for induction of general anaesthesia with orotracheal intubation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient requiring general anaesthesia with orotracheal intubation in the operating room

• Obese patient (Body Mass Index , BMI ≥ 30kg/m2)

• Patient affiliated to or benefiting from a social security scheme

• Patient having signed the free and informed consent form.

Locations
Other Locations
France
Clinique Pasteur
RECRUITING
Toulouse
Contact Information
Primary
Ségolène MROZEK, MD, PhD
smrozek@clinique-pasteur.com
+ 33 5 62 21 16 22
Backup
Stéphanie SAVY, PhD
ssavy@clinique-pasteur.com
+ 33 5 62 21 30 12
Time Frame
Start Date: 2025-06-19
Estimated Completion Date: 2027-03
Participants
Target number of participants: 124
Treatments
Active_comparator: Combined oxygenation procedure
Active_comparator: Single oxygenation procedure
Related Therapeutic Areas
Sponsors
Leads: Clinique Pasteur

This content was sourced from clinicaltrials.gov