Non-invasive Brain Stimulation to Prepare the Patient for Bariatric Surgery

Status: Recruiting
Intervention Type: Procedure, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Obesity is a chronic metabolic condition characterized by excessive accumulation of body fat, which triggers physiological mechanisms that increase the risk of a wide range of health problems. The most effective treatment for severe obesity is metabolic-bariatric surgery, which can lead to a 15-20% weight reduction, significantly lowering the risks of illness and death. However, the success of this surgery can be threatened by poor eating habits after the procedure. The main goal of this study is to enhance the long-term effectiveness of bariatric surgery by combining it with non-invasive brain stimulation (tDCS) targeting inhibitory centers before the operation. Additionally, the investigators aim to comprehensively monitor patients before and after surgery, focusing on investigating changes in brain function associated with the achieved weight loss.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Subjects with severe or morbid obesity (determined by BMI \> 35 or 40 kg/m2, respectively) eligible for BS treatment in compliance with the current guidelines

• Subjects who meet reduced control over eating behavior (disinhibition) criteria in the Eating Habits Questionnaire

Contact Information
Primary
Petra Holštajn Zemánková, Dr.
petra.zemankova@mail.muni.cz
+420 776 722 029
Backup
Sylvie Kropáčová, Dr.
sylvie.kropacova@ceitec.muni.cz
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 65
Treatments
Experimental: active tDCS stimulation
Participants in this arm will be stimulated for 4 weeks during weekdays leading to 20 sessions of tDCS over lDLPFC.
Sham_comparator: sham tDCS stimulation
In this arm, sham stimulation will be applied for 4 weeks during weekdays leading to 20 sessions of tDCS over lDLPFC.
Related Therapeutic Areas
Sponsors
Leads: Masaryk University
Collaborators: St. Anne´s University Hospital Brno

This content was sourced from clinicaltrials.gov

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