Pilot Study on the Analysis of the Metabolic Phenotype in Individuals With Difficulties in Losing and Gaining Weight
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This study examines why some individuals with obesity have difficulty losing weight, whereas some lean individuals struggle to gain weight. The investigators will measure how the human body uses energy during a fasting period and after consumption of a specially designed, low-protein meal. By comparing these responses, the investigators aim to identify different metabolic phenotypes that affect weight control. Findings from this research may lead to more personalized treatments for managing weight. Participation in this study involves simple tests and basic body measurements.
• Healthy status as determined by medical history, physical examination, and laboratory tests
• Stable weight (less than 5% fluctuation) over the past 6 months
Locations
Other Locations
Germany
University Hospital Schleswig-Holstein
RECRUITING
Kiel
Contact Information
Primary
Tim Hollstein, PD Dr. med.
tim.hollstein@uksh.de
+4943150022000
Time Frame
Start Date:2024-09-16
Estimated Completion Date:2025-08-01
Participants
Target number of participants:20
Treatments
Lean individual with weight gain difficulties
Participants in this group are lean individuals (BMI 18.5-22.0 kg/m²) who have difficulty gaining weight. They will undergo a 24-hour fasting period followed by a controlled low-protein, high-calorie meal test. Researchers will measure their resting metabolic rate before and after fasting, as well as the body's response to the test meal. By comparing these results to those of other groups, the study aims to identify metabolic factors that influence weight gain difficulties and guide future personalized treatments.
Individuals with obesity and weight loss difficulties
Participants in this group are individuals with obesity (BMI \>30 kg/m²) who have difficulty losing weight. They will undergo a 24-hour fasting period followed by a controlled low-protein, high-calorie meal test. Researchers will measure their resting metabolic rate before and after fasting, as well as the body's response to the test meal. By comparing these findings with those of other groups, the study seeks to uncover metabolic factors that contribute to weight loss difficulties and guide more personalized treatment approaches.