Examination of Preoperative and Postoperative Serum Amino Acid Metabolism in Individuals Undergoing Bariatric Surgery
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
This observational study aims to investigate the changes in serum amino acid metabolism before and after bariatric surgery in obese individuals. Blood samples will be collected from 50 patients at baseline (preoperative), and at 1 and 3 months postoperatively. An additional 50 healthy individuals will serve as the control group. Amino acid profiling will be conducted using LC-MS/MS. The study seeks to determine how bariatric surgery affects metabolic pathways associated with amino acid regulation.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:
• Age ≥18 years
• Diagnosed with obesity and scheduled for bariatric surgery (study group)
• Healthy individuals with normal BMI (control group)
Locations
Other Locations
Turkey
Veli Fahri Pehlivan
RECRUITING
Sanliurfa
Contact Information
Primary
Faik Tatlı, Prof. Dr
faiktatli-@harran.edu.tr
+90 542 327 67 62
Backup
Mehmet Gerger, Prof Dr
mehmetgerger93@gmail.com
+90 544 893 2363
Time Frame
Start Date: 2025-06-11
Estimated Completion Date: 2025-11-10
Participants
Target number of participants: 100
Treatments
Group 1: Bariatric surgery patients (n=50)
Participants in this group are adults (≥18 years old) with obesity who are scheduled to undergo bariatric surgery at Harran University Hospital. Blood samples will be collected at three time points: before surgery (baseline), and at 1 and 3 months postoperatively. Serum will be separated and stored at -80°C for subsequent amino acid profiling using LC-MS/MS.
Group 2: Healthy control participants (n=50)
Participants in this group are healthy adults (≥18 years old) with no known history of obesity or chronic metabolic disease. A single blood sample will be collected at baseline. Serum samples will be analyzed using LC-MS/MS to determine amino acid profiles, which will be compared to those of the bariatric surgery group.
Related Therapeutic Areas
Sponsors
Leads: Harran University