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Assessment of the Effect of Sirtuin Activator Supplementation on Cellular, Metabolic and Anthropometric Parameters in Women

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are: Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing? Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status. Participants will: Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 40
Maximum Age: 65
Healthy Volunteers: t
View:

• females

• age: 40-65 years

• overweight or obese: BMI \>25 kg/m2

Locations
Other Locations
Poland
Poznan University of Life Sciences
RECRUITING
Poznan
Contact Information
Primary
Agata Chmurzynska, Professor
agata.chmurzynska@up.poznan.pl
+486184661
Time Frame
Start Date: 2025-10-08
Estimated Completion Date: 2027-03-01
Participants
Target number of participants: 120
Treatments
Experimental: Experimental: sirtuin activators
Sirtuin activators supplementation for 6 months, daily dose of 1278 mg, taken twice a day in a capsulated form. Daily dose will contain: resveratrol - 500 g, leucin - 467 mg, Epigallocatechin gallate - 100 mg, quercetin - 100 mg, curcuminoids - 100 mg, niacin 10.7 g. Daily number of capsules will be 2 x 2 = 4.
Placebo_comparator: Placebo comparator: placebo
Placebo will be an inactive substance (maltodextrin) provided in the same-looking capsules as sirtuin activators. Placebo will be administered twice a day, daily number of capsules will be 2 x 2 = 4.
Related Therapeutic Areas
Sponsors
Collaborators: Poznan University of Medical Sciences, Nutropharma sp. z o.o.
Leads: Poznan University of Life Sciences

This content was sourced from clinicaltrials.gov

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