Multiomic Evaluation of the Effect of Artichoke By-products Supplementation Rich in Hydroxycinnamic Acids, Integrated Into an Energy-restricted Mediterranean Diet, on the Prevention of Type 2 Diabetes.
The ARTI-UP study evaluates whether daily consumption of a supplement made from artichoke by-products, rich in hydroxycinnamic acids (HCAs), in combination with an energy-restricted Mediterranean diet (erMeDiet), can improve glycaemic control, reduce insulin resistance and contribute to weight loss in subjects with overweight or obesity. In addition, it seeks to understand the biological mechanisms involved using omic techniques and to establish predictive biomarkers that will enable progress towards personalised nutrition strategies.
• BMI between 25.0 and 35.0 kg/m²
• HOMA-IR ≥ 2.5.
• Adequate physical examination and vital signs or clinically irrelevant to the intervention (those not related to metabolic health).
• Subjects must be able to understand and be willing to sign the informed consent form, and must comply with all study procedures and requirements.
• Subjects must have a stable means of communication, either by email and/or telephone.