Efficacy and Safety of NNC0487-0111 s.c. Once Weekly in Participants With Obesity Who Have Reached Target Dose During run-in Period (AMAZE 12)
Status: Recruiting
Location: See all (72) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Male or female (sex at birth).
• Age 18 years or above at the time of signing the informed consent.
Locations
United States
Alabama
Pinnacle Research Group LLC
ACTIVE_NOT_RECRUITING
Anniston
California
Diablo Clinical Research, Inc.
ACTIVE_NOT_RECRUITING
Walnut Creek
Florida
Florida Inst For Clin Res LLC
ACTIVE_NOT_RECRUITING
Orlando
Illinois
Endeavor Health
ACTIVE_NOT_RECRUITING
Skokie
Indiana
Midwest Inst For Clin Res
ACTIVE_NOT_RECRUITING
Indianapolis
North Carolina
Medication Mgmnt, LLC_Grnsboro
ACTIVE_NOT_RECRUITING
Greensboro
PMG Research of Wilmington LLC
ACTIVE_NOT_RECRUITING
Wilmington
Pennsylvania
UPA Ctr Weight and Eating Dis
ACTIVE_NOT_RECRUITING
Philadelphia
Rhode Island
Clinical Res Collaborative
ACTIVE_NOT_RECRUITING
Cumberland
Texas
North Texas Endocrine Center
NOT_YET_RECRUITING
Dallas
UT Southwestern Med Cntr
ACTIVE_NOT_RECRUITING
Dallas
Virginia
Selma Medical Associates
ACTIVE_NOT_RECRUITING
Winchester
Washington
Rainier Clin Res Ctr Inc
ACTIVE_NOT_RECRUITING
Renton
Other Locations
Argentina
CIPREC Pueyrredon
ACTIVE_NOT_RECRUITING
Buenos Aires
Conexa
ACTIVE_NOT_RECRUITING
Ciudad Autonoma De Buenos Aires
CICEMO- Consultorio (Av Directorio)
ACTIVE_NOT_RECRUITING
Ciudad Autónoma De Buenos Aires
Instituto de Investigaciones Clinicas Mar Del Plata
ACTIVE_NOT_RECRUITING
Mar Del Plata
Australia
Nightingale Research Adelaide
RECRUITING
Adelaide
Sydney Clinical Trials
RECRUITING
Campbelltown
Sydney Cardiometabolic Centre
RECRUITING
Liverpool
Hunter Diabetes Centre
RECRUITING
Merewether
Belgium
Anima Research Center
ACTIVE_NOT_RECRUITING
Diepenbeek
AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie
RECRUITING
Kortrijk
Centre hospitalier universitaire de Liège (CHU de Liège)
ACTIVE_NOT_RECRUITING
Liège
AZ OOSTENDE (Campus DAMIAAN)
NOT_YET_RECRUITING
Ostend
Bulgaria
DCC 1 - Lom EOOD
ACTIVE_NOT_RECRUITING
Lom
AIPSOMCEMD ENDO MED CONSULT 2020 - Dr. Aleksander Botushanov EOOD
ACTIVE_NOT_RECRUITING
Plovdiv
MHAT Med Line Clinic
ACTIVE_NOT_RECRUITING
Plovdiv
UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic
ACTIVE_NOT_RECRUITING
Plovdiv
AIPSMC Dr. Traykovska EOOD
ACTIVE_NOT_RECRUITING
Sofia
Medical Center Maraya Med EOOD
ACTIVE_NOT_RECRUITING
Sofia
SGHAT Dr. Shterev EOOD
ACTIVE_NOT_RECRUITING
Sofia
UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases
ACTIVE_NOT_RECRUITING
Sofia
Denmark
Sydvestjysk Sygehus Esbjerg - Medicinsk Endokrinologisk Ambulatorium, Forskningsenheden
ACTIVE_NOT_RECRUITING
Esbjerg
Sjællands Universitetshospital, Køge - Medicinsk Afdeling
ACTIVE_NOT_RECRUITING
Køge
Sanos Clinic - Vejle
RECRUITING
Vejle
France
CHU DE CLERMONT-FERRAND-HOPITAL GABRIEL MONTPIED_Service de Nutrition
ACTIVE_NOT_RECRUITING
Clermont-ferrand
CHU GRENOBLE ALPES-SITE NORD MICHALLON_Endocrinologie,diabétologie,maladies de la nutrition
ACTIVE_NOT_RECRUITING
La Tronche
GROUPE SOS SANTE-HOPITAL LE CREUSOT-HOTEL DIEU_ Service de Diabétologie
ACTIVE_NOT_RECRUITING
Le Creusot
CHU LILLE-HOPITAL CLAUDE HURIEZ_Service de Chirurgie Générale et Endocrinienne
ACTIVE_NOT_RECRUITING
Lille
CHU DE POITIERS_Centre d'investigation Clinique
ACTIVE_NOT_RECRUITING
Poitiers
Germany
Wendisch - Dahl Hamburg - DZHW
RECRUITING
Hamburg
Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH
ACTIVE_NOT_RECRUITING
Leipzig
Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz
ACTIVE_NOT_RECRUITING
Lingen
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
ACTIVE_NOT_RECRUITING
Münster
RED-Institut für medizinische Forschung und Fortbildung GmbH
ACTIVE_NOT_RECRUITING
Oldenburg In Holstein
Zentrum für klinische Studien Alexander Segner
ACTIVE_NOT_RECRUITING
Saint Ingbert-oberwürzbach
Diabetologikum - Diabetologische Schwerpunktpraxis Dr. Thomas Segiet
ACTIVE_NOT_RECRUITING
Speyer
Italy
A.O.Universitaria S.ORSOLA-MALPIGHI - U.O.Endocrinologia e Cura
ACTIVE_NOT_RECRUITING
Bologna
Arcispedale Sant'Anna (Cona) - UO di Endocrinologia
NOT_YET_RECRUITING
Ferrara
IRCCS Ospedale Policlinico San Martino - Medicina Interna e Specialità Mediche
ACTIVE_NOT_RECRUITING
Genoa
Azienda Ospedaliera di Padova - UOSD Chirurgia Bariatrica
NOT_YET_RECRUITING
Padova
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - Presidio Villa Belmonte
ACTIVE_NOT_RECRUITING
Palermo
Fondazione Salvatore Maugeri I.R.C.C.S. - Pavia - Dipartimento Medicina Interna e Generale
ACTIVE_NOT_RECRUITING
Pavia
IRCCS Humanitas - U.O. Endocrinologia e Diabetologia
ACTIVE_NOT_RECRUITING
Rozzano (mi)
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Geriatria
ACTIVE_NOT_RECRUITING
Verona
Netherlands
Progress Clinical Research Den Bosch
RECRUITING
's-hertogenbosch
EB Flevo Research BV
RECRUITING
Almere Stad
Meander MC
NOT_YET_RECRUITING
Amersfoort
Rijnstate Ziekenhuis
RECRUITING
Arnhem
PreCare Trial & Recruitment
RECRUITING
Born
Spain
Centro Periferico De Especialidades Bola Azul
ACTIVE_NOT_RECRUITING
Almería
Hospital Clinic i Provincial
ACTIVE_NOT_RECRUITING
Barcelona
H. de León_Endocrinología
ACTIVE_NOT_RECRUITING
León
Hospital Clínico San Carlos
ACTIVE_NOT_RECRUITING
Madrid
H. Clinico Univ. Virgen de la Victoria
ACTIVE_NOT_RECRUITING
Málaga
H.U. Quirónsalud Madrid
ACTIVE_NOT_RECRUITING
Pozuelo De Alarcón
Hospital Universitario Virgen del Rocío
ACTIVE_NOT_RECRUITING
Seville
United Kingdom
EMS Healthcare
RECRUITING
Macclesfield
Clifton Medical Centre
RECRUITING
Rotherham
Staploe Medical Centre
RECRUITING
Soham
Albany House Medical Centre
RECRUITING
Wellingborough
Contact Information
Primary
Novo Nordisk
clinicaltrials@novonordisk.com
(+1) 866-867-7178
Time Frame
Start Date: 2026-04-21
Estimated Completion Date: 2028-07-04
Participants
Target number of participants: 600
Treatments
Experimental: NNC0487-0111
Participants will receive subcutaneous injection of NNC0487-0111 once weekly as an adjunct to a reduced-calorie diet and increased physical activity.
Placebo_comparator: Placebo
Participants will receive subcutaneous injection of placebo matched to NNC0487-0111 once weekly as an adjunct to a reduced-calorie diet and increased physical activity.
Related Therapeutic Areas
Sponsors
Leads: Novo Nordisk A/S