The Effects of Total Intravenous Anesthesia and Inhalational Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity. The investigators believe that the anesthesia method we apply with inhalation gases is also as reliable method as total intravenous anesthesia for postoperative cognitive functions in these patients who undergoe sleeve gastrectomy. The anesthesia method applied intravenously and with inahalational gases have been applied safely for many years. Comparisons between these two anesthesia technics in obese individuals and for postoperative cognitive dysfunctions are limited. Studies on the examination of cognitive functions in postoperative patients have gained momentum with the use of neuropsychiatric tests performed on patients who have undergone cardiac surgery and these tests have also been performed on individuals who have undergone non-cardiac surgery. And yet, similar declines in cognitive functions have been observed. For these reasons, the effects of surgery itself and anesthesia methods on cognitive functions have been studied up to date. In this study, the investigators plan to evaluate patients who will undergo obesity surgery in both anesthesia methods by the recovery times from anesthesia and the residual effects of anesthesia, and after awakening they plan to evaluate their cognitive functions with neuropsychiatric tests that will be performed at certain intervals.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Patients of both sexes, Patients Aged between 18 and 65 years, Patients classified as ASA(American Society of Anesthesiologists) physical status I- III, Patients with a BMI (Body Mass Index) between 35 and 50 kg/m² scheduled to undergo sleeve gastrectomy as a type of bariatric surgery for the first time.
Locations
Other Locations
Turkey
Şehit Prof. Dr. İlhan Varank Sancaktepe Training and Research Hospital
RECRUITING
Istanbul
Contact Information
Primary
Evin ERGÜN KASAP
evinergun341694@gmail.com
+90216-606-33-00
Backup
Nuray Turkut
drnturkut@gmail.com
+90538-583-28-38
Time Frame
Start Date:2025-09-30
Estimated Completion Date:2026-07-30
Participants
Target number of participants:60
Treatments
Total Intravenous Anesthesia
We planned to visit patients who will undergo sleeve gastrectomy the day before the surgery and perform MMST and ACE tests. All patients will undergo electrocardiogram, pulse oxygen saturation, arterial blood pressure monitoring and bispectral index and near infrared spectroscopy. Induction agents will be used according to ideal body weights, and after intubation, ventilation parameters will be set to ventilation control mode/pressure control mode, taking into account ideal body weights and lung protective mechanical ventilation parameters. All monitoring parameters will be noted. Total Intravenous Anesthesia group will receive propofol and remifentanil infusions. Dose adjustments will be made according to hemodynamic parameters, NIRS and BIS values, and the total dose used throghout will be noted.~Postoperative eye opening, extubation and recovery times will be noted and both groups are going to be evaluated by postoperative cognitive tests at certain postoperative intervals.
Inhalational Anesthesia
We planned to visit patients who will undergo sleeve gastrectomy the day before the surgery and perform MMST ve ACE tests. All patients will undergo electrocardiogram, pulse oxygen saturation, arterial blood pressure monitoring and bispectral index and near infrared spectroscopy. Induction agents will be used according to ideal body weights, and after intubation, ventilation parameters will be set to ventilation control mode/pressure control mode, taking into account ideal body weights and lung protective mechanical ventilation parameters. All monitoring parameters will be noted. Inhalational Anesthesia group will receive sevoflurane and remifentanyl infusion. EtSevo and total remifentanyl doses will be noted as adjusted with hemodynamic parameters, NIRS, BIS values accordingly.~In both groups, postoperative eye opening, extubation and recovery times will be noted and both groups are going to be evaluated by applying postoperative cognitive tests at certain postoperative intervals.