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A Phase 1, Investigator- and Participant-Blinded Study to Evaluate the Effect of Eloralintide on Insulin Sensitivity and Metabolism in Adult Participants With Overweight or Obesity

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

The main purpose of the study is to measure and compare the effects of eloralintide and placebo on insulin sensitivity (how your body responds to insulin), metabolic health (things like sugar and cholesterol), and body weight in participants with obesity or overweight. For each participant, the study will last about 35 weeks and include 3 in patient visits totaling 7 days.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:

• Have an hemoglobin A1c (HbA1c) value at screening of less than 6.5 percent (%).

• Have a body mass index between 25 and 45 Kilogram per Square Meter (kg/m²).

• Have had a stable body weight that has changed by less than 5% during the 3 months prior to screening.

• Are individuals assigned male at birth (AMAB) or assigned female at birth (AFAB). Individuals of childbearing potential (IOCBP) and individuals not of childbearing potential (INOCBP) may participate in this study.

Locations
Other Locations
Germany
Profil Institut für Stoffwechselforschung
RECRUITING
Neuss
Sweden
CTC GoCo
NOT_YET_RECRUITING
Mölndal
Contact Information
Primary
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
LillyTrials@Lilly.com
1-317-615-4559
Backup
Physicians interested in becoming principal investigators please contact
clinical_inquiry_hub@lilly.com
Time Frame
Start Date: 2026-06-24
Estimated Completion Date: 2027-08
Participants
Target number of participants: 115
Treatments
Experimental: Eloralintide
Eloralintide administered subcutaneously (SC)
Placebo_comparator: Placebo
Placebo administered SC
Related Therapeutic Areas
Sponsors
Leads: Eli Lilly and Company

This content was sourced from clinicaltrials.gov

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