Interpretation Bias as a Mechanism of Treatment Response in OCD

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I. Adults with obsessive compulsive disorder (OCD) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive: 1) up to 12 sessions of CBM-I, or or up to 12 sessions of psychoeducation as a control condition.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• 1\) OCD Institute patients

• 2\) adults (\> 18 years old)

• 3\) able to complete a computer task for 20 minutes

• 4\) consent to main OCD Institute study protocol

• 5\) primary diagnosis of OCD (as measured by a score of \>16 on the Y-BOCS and a clinical diagnosis of OCD by their treatment team

• 6\) score of \>131 on the Obsessive Beliefs Questionnaire-44 at admission \[which is 1 SD above the mean score of the non-clinical sample reported in the original validation paper by the Obsessive Compulsive Cognitions Working Group (2005)\]

Locations
United States
Massachusetts
McLean Hospital
RECRUITING
Belmont
Contact Information
Primary
Martha Falkenstein, PhD
mfalkenstein@mclean.harvard.edu
617-855-4424
Time Frame
Start Date: 2022-03-30
Estimated Completion Date: 2026-08-31
Participants
Target number of participants: 106
Treatments
Experimental: Cognitive bias modification with treatment as usual
Participants in this group will receive usual treatment in the program up to 12 sessions of a digital cognitive training targeting interpretation bias
Sham_comparator: Psychoeducation with treatment as usual
Participants in this group will receive usual treatment in the program up to 12 sessions of digitized psychoeducation
Related Therapeutic Areas
Sponsors
Leads: Mclean Hospital

This content was sourced from clinicaltrials.gov