Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
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• Healthy adults
• 18 - 45 years of age
• Living in Calgary for the past one year
• Have no medical condition or should not be taking any blood pressure medications.
• The participant should not be lactose intolerant
Locations
Other Locations
Canada
University of Calgary
RECRUITING
Calgary
Time Frame
Start Date: 2023-01-01
Estimated Completion Date: 2027-12-30
Participants
Target number of participants: 12
Treatments
Active_comparator: CBF Lowering and Normoxia Sleep
Study participants will take drug lowering Cerebral Blood Flow (CBF) and sleep under room air i.e. normoxia exposure.
Experimental: CBF Lowering and IH Sleep
Study participants will take drug lowering Cerebral Blood Flow (CBF) and sleep under Intermittent Hypoxia (IH) exposure.
Sham_comparator: Placebo and Normoxia Sleep
Study participants will take Placebo that has no effect on Cerebral Blood Flow (CBF) and sleep under room air i.e. normoxia exposure.
Placebo_comparator: Placebo and IH Sleep
Study participants will take Placebo that has no effect on Cerebral Blood Flow (CBF) and sleep under Intermittent Hypoxia (IH) exposure.
Related Therapeutic Areas
Sponsors
Leads: University of Calgary