Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG). The aim of the present prospective, multi-center, case-control study is to identify susceptibility genes/loci for PXF, PACG and POAG using a whole genome association (WGA) approach.
• For patients with PXF:
‣ Patients with confirmed pseudoexfoliation syndrome (exfoliation glaucoma / pseudoexfoliation of the lens) in the medical history
⁃ Informed consent
⁃ Age 50 years or more
• For patients with PACG:
‣ Patients with confirmed acute primary angle closure (PAC) or primary angle closure glaucoma (PACG) in the medical history
⁃ Informed consent
⁃ Age 21 years or more
• For healthy controls:
‣ No evidence of PXF, glaucoma or uveitis during clinical examination or in the medical history
⁃ No evidence of major ocular disease such as diabetic retinopathy, age related macular degeneration or conditions with genetic background during clinical examination or in the medical history
⁃ Age more than 60 years
⁃ Informed consent
• For patients with POAG:
‣ Patients with confirmed primary open angle glaucoma (POAG)
⁃ No evidence of exfoliation glaucoma / pseudoexfoliation of the lens or pigment glaucoma
⁃ Informed consent
⁃ Age 30 or more