Opioid Use Disorder and Pain

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Observational
SUMMARY

The goal of this observational study is to characterize the brain processes of pain avoidance learning dysfunctions in individuals with opioid use disorder (OUD). The main questions it aims to answer are: Compared with healthy controls, do those with OUD exhibit impaired avoidance learning in response to pain? What are the brain processes that are associated with this avoidance learning dysfunction? Do these brain processes serve to predict future use or relapse? Researchers will compare those with OUD and healthy controls to determine avoidance learning dysfunction and its relationship with opioid use. Participants will be performing a learning task inside an fMRI scanner. Those with OUD will also be followed up for a year to determine future opioid use.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 60
Healthy Volunteers: t
View:

• Between ages 1821-60 years old.

• Able to read and write and provide written informed consent.

• Demographics matching OUD participants.

• Speak English

Locations
United States
Connecticut
Connecticut Mental Health Center, S105
RECRUITING
New Haven
Contact Information
Primary
Thang M Le, PhD
thang.le@yale.edu
203-974-7360
Backup
Chiang-shan R Li, MD, PhD
chiang-shan.li@yale.edu
203-974-7354
Time Frame
Start Date: 2025-02-04
Estimated Completion Date: 2028-01
Participants
Target number of participants: 180
Treatments
opioid use disorder
individuals with OUD diagnosis
Healthy controls
Healthy individuals without substance use disorders
Related Therapeutic Areas
Sponsors
Leads: Yale University
Collaborators: National Institute on Alcohol Abuse and Alcoholism (NIAAA), Brain and Behavior Research Foundation (previously known as NARSAD)

This content was sourced from clinicaltrials.gov