Learn About Oral Squamous Cell Carcinoma

What is the definition of Oral Squamous Cell Carcinoma?
Oral squamous cell carcinoma is the most common mouth cancer (95%). Oral squamous cell carcinoma can develop in any part of the mouth, including the lips, gums, tongue, inner lining of the cheeks, roof of mouth, and floor of mouth. Oral squamous cell carcinoma can spread (metastasize) to other areas of the head and neck.
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What are the symptoms of Oral Squamous Cell Carcinoma?
Symptoms of oral squamous cell carcinoma may include a sore on the lip or mouth that does not heal, a sore that bleeds, a white or reddened patch inside the mouth, loose teeth, a lump or other growth in the mouth, neck lump, mouth and ear pain, a change in speech, and difficulty swallowing.
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What are the current treatments for Oral Squamous Cell Carcinoma?
Treatment for oral squamous cell carcinoma depends on the affected area and stage of the mouth cancer and may include surgery, radiation therapy, chemotherapy, targeted drug therapy (cetuximab), immunotherapy, reconstructive surgery, dental implants, and speech and occupational rehabilitation. Individuals with oral squamous cell carcinoma should quit smoking or other tobacco products and drinking alcohol. After treatment, individuals who have had oral squamous cell carcinoma will need regular follow-up to check for cancer recurrence.
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What are the latest Oral Squamous Cell Carcinoma Clinical Trials?
Randomized Phase II/III Trial of Adjuvant Radiation Therapy With Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

Summary: This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and ...

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Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors

Summary: This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. There are four parts to this study. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). In Part B, participants will receive tisotumab vedotin on Days 1, 8, and 15 every 4-week cycle. In Part C, parti...

What are the Latest Advances for Oral Squamous Cell Carcinoma?
Efficacy of cetuximab plus PD-1 inhibitor differs by HPV status in head and neck squamous cell carcinoma: a systematic review and meta-analysis.
Neoadjuvant toripalimab combined with gemcitabine and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NeoTGP01): An open label, single-arm, phase Ib clinical trial.
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Randomized phase 3 noninferiority trial of radiotherapy and cisplatin vs radiotherapy and cetuximab after docetaxel-cisplatin-fluorouracil induction chemotherapy in patients with locally advanced unresectable head and neck cancer.