Exploring the Application Value of PET Molecular Imaging Targeting FAP in Oral Squamous Cell Carcinoma

Status: Recruiting
Location: See location...
Intervention Type: Device, Diagnostic test, Drug
Study Type: Observational
SUMMARY

In this prospective study, the investigators will use integrated PET/CT with the agent 68Ga-FAPI and conventional imaging agent 18F-FDG to explore the application value of FAP-targeted molecular imaging in the diagnosis and staging for oral cancer. This study also aims to explore the application value of FAPI imaging in evaluating treatment response for oral cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

• Voluntary participation with signed informed consent;

• Aged 18\

⁃ 70 years;

• Clinically highly suspected oral cancer and recurrence after treatment (Newly diagnosed patients: Scheduled for surgery or neoadjuvant therapy followed by surgery);

• Ability to complete baseline and follow-up PET/CT (Follow-up FAPI PET/CT applies only to locally advanced patients undergoing neoadjuvant therapy.).

Locations
Other Locations
China
Zhongnan Hopital of Wuhan University
RECRUITING
Wuhan
Contact Information
Primary
Jiang Yaqun, PhD
zn004239@whu.edu.cn
0086-027-67812698
Backup
He Yong, PhD
vincentheyong@163.com
0086-027-67812698
Time Frame
Start Date: 2021-09-15
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 100
Treatments
68Ga-DOTA-FAPI and 18F-FDG PET/CT
Investigators recruit patients whom are clinically highly suspected oral cancer or recurrence after treatment. Patients undergo baseline 68Ga-FAPI and 18F-FDG PET/CTwithin one week. For resectable locally advanced cases receiving neoadjuvant therapy from oral and maxillofacial clinicians, a follow-up FAPI PET imaging will be performed after two cycles of treatment and before surgery.
Related Therapeutic Areas
Sponsors
Leads: Zhongnan Hospital

This content was sourced from clinicaltrials.gov