What is the definition of Osmotic Diuresis?

Osmotic diuresis is increased urination due to the presence of certain substances in the fluid filtered by the kidneys. This fluid eventually becomes urine. The process of osmosis created by these substances cause additional water to come into the urine, increasing its amount.

What are the causes for Osmotic Diuresis?

Osmotic diuresis can be caused by:

  • High blood sugar (glucose)
  • Use of certain medicines, such as Mannitol


Kamel KS, Halperin ML. Interpretation of electrolyte and acid-base parameters in blood and urine. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 24.

Pfennig CL, Slovis CM. Electrolyte disorders. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 117.

  • Condition: Syndrome of Inappropriate Antidiuresis (SIAD)
  • Journal: Journal of the American Society of Nephrology : JASN
  • Treatment Used: Empagliflozin
  • Number of Patients: 87
  • Published —
This trial evaluated the use of empagliflozin to treat patients with syndrome of inappropriate antidiuresis (SIAD).
  • Condition: Type 2 diabetes
  • Journal: Diabetes & vascular disease research
  • Treatment Used: Ertugliflozin alone or with other antihyperglycaemic agents
  • Number of Patients: 1544
  • Published —
The study compared the outcomes of ertugliflozin alone or with other antihyperglycaemic agents for patients with type 2 diabetes.
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug
  • Participants: 20
  • Start Date: April 2021
Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence