Condition 101 About Osteochondritis Dissecans

What is the definition of Osteochondritis Dissecans?

Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. If the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. However, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. Although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years. In most cases, the exact underlying cause is unknown. Rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the ACAN gene and is inherited in an autosomal dominant manner. Treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy.

What are the alternative names for Osteochondritis Dissecans?

  • Kônig disease
  • König disease

What are the causes for Osteochondritis Dissecans?

In most cases, the exact underlying cause of osteochondritis dissecans is not completely understood. Scientists suspect that it may be due to decreased blood flow to the end of the affected bone, which may occur when repetitive episodes of minor injury and/or stress damage a bone overtime.

In some families, osteochondritis dissecans is caused by changes (mutations) in the ACAN gene. In these cases, which are referred to as familial osteochondritis dissecans, the condition generally affects multiple joints and is also associated with short stature and early-onset osteoarthritis. The ACAN gene encodes a protein that is important to the structure of cartilage. Mutations in this gene weaken cartilage, which leads to the various signs and symptoms of familial osteochondritis disssecans.

What are the symptoms for Osteochondritis Dissecans?

The signs and symptoms of osteochondritis dissecans vary from person to person. If the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. However, affected people may experience the following if the cartilage and bone travel into the joint space:
  • Pain, swelling and/or tenderness
  • Joint popping
  • Joint weakness
  • Decreased range of motion

Although osteochondritis dissecans can develop in any joint of the body, the knee, ankle and elbow are most commonly affected. Most people only develop the condition in a single joint.

What are the current treatments for Osteochondritis Dissecans?

The primary aim of treatment for osteochondritis dissecans is to restore normal function of the affected joint, relieve pain and prevent osteoarthritis. Treatment for the condition varies depending on many factors including the age of the affected person and the severity of the symptoms. In children and young teens, osteochondritis dissecans often heals overtime without surgical treatment. These cases are often managed with rest and in some cases, crutches and/or splinting to relieve pain and swelling.

If non-surgical treatments are not successful or the case is particularly severe (i.e. the cartilage and bone are moving around within the joint space), surgery may be recommended. Following surgery, physical therapy is often necessary to improve the strength and range of motion of the affected joint.

How is Osteochondritis Dissecans diagnosed?

A diagnosis of osteochondritis dissecans is usually suspected based on the presence of characteristic signs and symptoms. Additional testing can then be ordered to confirm the diagnosis. These test may include x-rays, magnetic resonance imaging (MRI) and/or computed tomography (CT scan).

For more information about the diagnosis of osteochondritis dissecans, please click here.

Latest Advances On Osteochondritis Dissecans

  • Condition: Osteochondritis Dissecans
  • Journal: Medicine
  • Treatment Used: Radiofrequency Coblation
  • Number of Patients: 1
  • Published —
In this study, researchers evaluated the outcomes of using radiofrequency coblation for the treatment of osteochondritis dissecans in an adolescent.
  • Condition: Unsalvageable Osteochondritis Dissecans
  • Journal: The American journal of sports medicine
  • Treatment Used: Autologous Chondrocyte Implantation
  • Number of Patients: 55
  • Published —
In this study, researchers evaluated the outcomes of autologous chondrocyte implantation for the treatment of unsalvageable osteochondritis dissecans.

Clinical Trials For Osteochondritis Dissecans

Clinical Trial
  • Status: Recruiting
  • Intervention Type: Procedure
  • Participants: 120
  • Start Date: January 4, 2021
Psychological Response and Readiness to Return to Sports Associated With the Diagnosis and Treatment of Osteochondritis Dissecans of the Knee
Clinical Trial
  • Status: Recruiting
  • Phase: N/A
  • Intervention Type: Device, Procedure
  • Participants: 40
  • Start Date: November 19, 2019
Biological Effects of a Bipolar Radiofrequency-based Device Over Shoulder Cartilage - a Randomized Controlled Clinical Trial