OsteosarcomaSymptoms, Doctors, Treatments, Advances & More
Learn About Osteosarcoma
Osteosarcoma is a rare type of cancerous bone tumor that usually develops in teenagers and young adults. It often occurs when a teen is growing rapidly.
Osteogenic sarcoma; Bone tumor - osteosarcoma
Osteosarcoma is the most common bone cancer in children. The average age at diagnosis is 15 years. Boys and girls are just as likely to develop this tumor until the late teens, after which it occurs more often in boys. Osteosarcoma is also common in people over age 60.
The cause is not known. In some cases, osteosarcoma runs in families. At least one gene has been linked to an increased risk. This gene is also associated with familial retinoblastoma. This is a cancer of the eye that occurs in children.
Osteosarcoma tends to occur in the bones of the:
- Shin (near the knee)
- Thigh (near the knee)
- Upper arm (near the shoulder)
Osteosarcoma occurs most commonly in large bones in the area of bone with the fastest growth rate. However, it can occur in any bone.
The first symptom is usually bone pain near a joint. This symptom may be overlooked, especially in young people, because of other more common causes of joint pain.
Other symptoms may include any of the following:
- Bone fracture (may occur after a routine movement)
- Limitation of motion
- Limping (if the tumor is in the leg)
- Pain when lifting (if the tumor is in the arm)
- Tenderness, swelling, or redness at the site of the tumor
Treatment usually starts after a biopsy of the tumor is done.
Before surgery to remove the tumor, chemotherapy, radiation therapy, or both is usually given. This can shrink the tumor and make surgery easier. It may also kill any cancer cells that have spread to other parts of the body.
Surgery is used after chemotherapy to remove any remaining tumor. In most cases, surgery can remove the tumor while saving the affected limb. This is called limb-sparing surgery. In rare cases, more extensive surgery (such as amputation) is necessary.
Carol Simon Cancer Center
James Wittig is an Orthopedics provider practicing medicine in Morristown, New Jersey. Dr. Wittig is rated as an Elite provider by MediFind in the treatment of Osteosarcoma. He is also highly rated in 28 other conditions, according to our data. His clinical expertise encompasses Osteosarcoma, Adult Soft Tissue Sarcoma, Ewing Sarcoma, Hip Replacement, and Knee Replacement. Dr. Wittig is board certified in American Board Of Orthopaedic Surgery. Dr. Wittig is currently accepting new patients.
Duke University Hospital
Lars Wagner is a Hematologist and an Oncologist practicing medicine in Durham, North Carolina. Dr. Wagner is rated as an Elite provider by MediFind in the treatment of Osteosarcoma. He is also highly rated in 20 other conditions, according to our data. His clinical expertise encompasses Osteosarcoma, Ewing Sarcoma, Adult Soft Tissue Sarcoma, Rhabdomyosarcoma, and Bone Marrow Aspiration. Dr. Wagner is currently accepting new patients.
Emanuela Palmerini is an Oncologist practicing medicine in Miami, Florida. Dr. Palmerini is rated as an Elite provider by MediFind in the treatment of Osteosarcoma. She is also highly rated in 14 other conditions, according to our data. Her clinical expertise encompasses Adult Soft Tissue Sarcoma, Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma. Dr. Palmerini is currently accepting new patients.
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you and your family not feel alone.
If the tumor has not spread to the lungs (pulmonary metastasis), long-term survival rates are better. If the cancer has spread to other parts of the body, the outlook is worse. However, there is still a chance of cure with effective treatment.
Complications may include:
- Limb removal
- Spread of cancer to the lungs
- Side effects of chemotherapy
Contact your provider if you or your child has persistent bone pain, tenderness, or swelling.
Summary: This phase I/II trial studies the effects of trastuzumab deruxtecan (DS-8201a) in treating patients with osteosarcoma, Wilms tumor (WT) or desmoplastic small round cell tumor (DSRCT) that is newly diagnosed or has come back after a period of improvement (recurrent) or that has not responded to previous treatment (refractory). Trastuzumab deruxtecan is in a class of medications called antibody-drug...
Summary: This is a first-in-human, open-label, non-randomized, three-part phase 1 trial of INBRX-109, which is a recombinant humanized tetravalent antibody targeting the human death receptor 5 (DR5).
Published Date: October 14, 2024
Published By: Warren Brenner, MD, Oncologist, Lynn Cancer Institute, Boca Raton, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Anderson ME, DuBois SG, Gebhardt MC. Sarcomas of bone. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 89.
National Cancer Institute website. Osteosarcoma and undifferentiated pleomorphic sarcoma of bone treatment (PDQ) - health professional version. www.cancer.gov/types/bone/hp/osteosarcoma-treatment-pdq. Updated December 2, 2024. Accessed March 18, 2025.