Randomized Phase III Trial of Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Platinum-Resistant Recurrent Ovarian Cancer: KOV-02R - Resistant Cancer of Ovary (RECOVER)
Platinum-resistant recurrent epithelial ovarian cancer randomizing with or without cytoreductive surgery + hyperthermic intraperitoneal chemotherapy (HIPEC): KOV-02R, RECOVER
⁃ Patients ≥18 years old,
• Patients with Eastern Cooperative Oncology Group (ECOG) Performance status 0-2,
• Patients diagnosed with histologically confirmed epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer,
• Resistant to platinum-based chemotherapy (Platinum-refractory or resistant disease)
• Resectable intraperitoneal disease based on previous clinical history and recent image finding,
• A life expectancy \> 3 months as clinically judged,
• Women who are medically unable to conceive or who are of childbearing potential, agree to follow contraceptive guidelines during treatment,
• Patient can also consent to the provision of clinical information for secondary use such as future biomedical research. However, in the future, subjects can participate in the main trial even if they do not intend to participate in sharing clinical information and,
• Adequate organ function for cytoreductive surgery and HIPEC