Androgens and Nonalcoholic Fatty Liver Disease (NAFLD) In Reproductive-Aged Women With and Without Polycystic Ovary Syndrome (PCOS)
Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY
The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can cause damage to the liver such as inflammation or scarring. Young women with a condition called polycystic ovary syndrome (PCOS) have a high risk for NAFLD, and they often have high androgen levels too. So the researchers are recruiting young women with PCOS as well as those without PCOS, and will compare changes in NAFLD over time between young women with and without PCOS. This study is funded by the National Institutes of Health
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 42
Healthy Volunteers: f
View:
• Metabolic associated steatohepatitis (MASH) (formerly NASH)
• PCOS
• Non-PCOS
Locations
United States
California
University of California San Francisco
RECRUITING
San Francisco
North Carolina
Duke University
NOT_YET_RECRUITING
Durham
Contact Information
Primary
Elle K Oberweis-Manion, B.A.
myliverhealth@ucsf.edu
415-502-3725
Time Frame
Start Date: 2024-01-22
Estimated Completion Date: 2028-12
Participants
Target number of participants: 150
Treatments
MASLD and PCOS hyperandrogenism
Patients with MASLD and PCOS with the phenotype of hyperandrogenism
MASLD and PCOS non-hyperandrogenism
Patients with MASLD and PCOS with the phenotype of non-hyperandrogenism
MASLD and no-PCOS
Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and no PCOS
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Duke University
Leads: University of California, San Francisco