Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome: A Prospective Comparative Randomized Blinded Trial.

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

In PCOS (Polycystic Ovary Syndrome), studies have found impaired incretin secretion and activity, particularly in overweight/obese individuals. Conflicting results exist regarding glucagon-like peptide-1(GLP-1) levels in PCOS patients, with studies reporting reduced, normal, or increased levels. Incretin-based therapy has been suggested as a potential treatment to reverse prediabetes risk by preserving β-cell function in patients with impaired fasting glucose(IFG and impaired glucose tolerance(IGT). The study aims to compare the efficacy of Dapagliflozin to Metformin for the treatment of non-diabetic patients with polycystic ovary syndrome (PCOS).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 40
Healthy Volunteers: f
View:

• Women diagnosed with PCOS according to Rotterdam 2003 criteria National Institute of Health criteria.

• Age: \>18 \<40 years.

• Infertile women (primary or secondary infertility)

Locations
Other Locations
Egypt
October 6 University Hospital
RECRUITING
Giza
Contact Information
Primary
Nouran Omar
nomar@fue.edu.eg
01006526452
Time Frame
Start Date: 2024-09-02
Estimated Completion Date: 2025-01
Participants
Target number of participants: 70
Treatments
Active_comparator: Dapagliflozin
Patients will receive Dapagliflozin 10 mg once daily orally for 12 weeks (Forxiga® AstraZeneca company)
Active_comparator: Metformin
Patients will receive Metformin 1000 mg once daily orally for 12 weeks (control group) (Glucophage® Merck company)
Sponsors
Leads: Future University in Egypt
Collaborators: October 6 University

This content was sourced from clinicaltrials.gov

Similar Clinical Trials