Ovarian Hyperstimulation Syndrome Clinical Trials

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Efficacy and Safety of Biphasic IVM in Low Prognosis Patients Classified as Poseidon Group 1A

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if biphasic In Vitro Maturation (IVM) works to help young women who produce very few oocytes after controlled ovarian stimulation. The study focuses on women under age 35 who have a good number of follicles in their ovaries but do not respond well to standard ovarian stimulation by Gonadotropin (known as POSEIDON Group 1a). The main questions it aims to answer are: How many mature oocytes can be obtain after biphasic -VM? Researchers will use biphasic-IVM system to see if it can bypass the problems these patients face with standard treatments, such as high costs and the risk of medical complications like Ovarian Hyperstimulation Syndrome (OHSS). Participants will: Have their immature eggs collected from the ovaries without the need for high-dose hormone injections. Have their eggs matured in a specialized laboratory using a two-step process (biphasic IVM) to improve egg quality. Follow up with researchers to check the number of embryos created and the safety of the procedure.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 35
Healthy Volunteers: f
View:

• Women aged 18 - \< 35 years

• At least one IVF cycle have been failed and classified as having a poor response to POSEIDON group Ia.

• POSEIDON group Ia ( \< 35 age; AMH \>= 1.2 ng/ml and/or AFC \>=5 antral follicles; have \< 4 oocytes was retrieved at previous IVF cycle)

• Agree to apply biphasic-IVM treatment.

• Agree to freeze all embryos and to transfer the frozen embryos afterward.

• Agree to participate in the study.

Locations
Other Locations
Viet Nam
IVFMD, My Duc Hospital
RECRUITING
Ho Chi Minh City
Contact Information
Primary
Ho L. Le, MD
bsho.ll@myduchospital.vn
+84356177147
Backup
Tuong M Ho, MD
tuongho.ivfmd@gmail.com
+84903633377‬
Time Frame
Start Date: 2026-06-12
Estimated Completion Date: 2027-03-30
Participants
Target number of participants: 25
Treatments
Experimental: Biphasic-IVM
Participants in this arm will undergo a biphasic In Vitro Maturation (IVM) protocol
Related Therapeutic Areas
Sponsors
Leads: Mỹ Đức Hospital

This content was sourced from clinicaltrials.gov