Cohort 1

Individuals without history of PDAC meeting any of the following criteria:~A. 2+ relatives with PDAC on same side of family; 2 are first degree related to each other and at least 1 is first degree related to subject; age ≥ 50 years or ≤10 years younger than earliest PDAC in family at diagnosis.~B. 2+ first degree relatives with PDAC; age ≥ 50 years or ≤ 10 years younger than earliest PDAC in family at diagnosis.~C. BRCA1, BRCA2, PALB2, ATM, MLH1, MSH2, MSH6, PMS2, EPCAM pathogenic or likely pathogenic variant AND 1 first or second degree relative with PDAC; age ≥ 50 years or ≤ 10 years younger than earliest PDAC in family at diagnosis.~D. Familial Atypical Moles and Malignant Melanoma (FAMMM) with pathogenic or likely pathogenic CDKN2A variant; age ≥ 40 years.~E. Peutz-Jegher syndrome with STK11 pathogenic or likely pathogenic variant; age ≥35 years.~F. Hereditary pancreatitis with PRSS1 pathogenic or likely pathogenic variant and history of pancreatitis; age ≥ 40 years.

Cohort 2

Individuals without history of PDAC meeting any of the following criteria:~A. ATM, BRCA1, BRCA2, or PALB2 pathogenic or likely pathogenic variant regardless of family history; age ≥50 years.~B. Two or more (2+) relatives with PDAC on the same side of family, any degree of relation, not meeting other criteria above; age ≥50 years or ≤10 years younger than earliest PDAC in family at time of diagnosis.~C. One (1) first degree relative with PDAC at age ≤45 years; ≤10 years younger than PDAC diagnosis in family member at time of diagnosis.

Cohort 3

A. Individuals meeting criteria for Cohorts 1 or 2 EXCEPT age (i.e. too young to qualify for Cohorts 1 or 2); age ≥ 18 years.

Cohort 4

A. Individuals without history of PDAC presenting for evaluation who do not meet any criteria for the other cohorts after collection of full family history and/or germline testing, eg. they have only 1 relative with PDAC; age ≥ 18 years.

Cohort 5 - Personal history of PDAC

Individuals with a personal history of PDAC meeting any of the following criteria (age ≥ 18 years for all subgroups):~A. Family history includes at least one first degree relative with PDAC, or 2 relatives with PDAC who are first degree related to each other.~B. Personal or family history of a pathogenic or likely pathogenic germline variant in ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11.~C. Diagnosed with PDAC at ≤ age 45.

Cohort 6 - Pancreatic cysts

Individuals with pancreatic cysts (age ≥ 18 years for all subgroups):~A. Individuals with a pancreatic cystic neoplasm (IPMN) and/or mucinous cystic neoplasm (MCN) and/or PanIN not meeting any criteria for Cohorts 1-3 or 6 (no personal history of PDAC, no known family history of PDAC, no known pathogenic germline variants linked to PDAC risk present in cohorts 1C, 2A, 1D, 1E, and 1F).~B. Individuals with a pancreatic cystic neoplasm (IPMN) and/or MCN and/or PanIN without PDAC and with at least one of the pathogenic or likely pathogenic gene mutations present in cohorts 1C, 2A, 1D, 1E, and 1F and/or a first degree relative with PDAC.

Cohort 7 - Acute or chronic pancreatitis

Individuals with a personal history of pancreatitis meeting any of the following criteria (age ≥ 18 years for all subgroups):~A. Chronic pancreatitis. B. At least 2 episodes of acute pancreatitis.

Cohort 8 - PDAC stages I-II or clinical suspicion

Individuals with one of the following conditions and treatment naïve (age ≥ 18 years for all subgroups):~A. Biopsy-proven, clinical stage I-II PDAC and candidate for surgical resection.~B. Clinical findings suspicious for early stage PDAC prior to biopsy.