Diagnostic Efficacy of 18F-FAPI-74 PET/CT in Patients With Pancreatic Cancer

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY

Staging pancreatic cancer (PC) presents a clinical challenge. Triphasic whole body CT is the primary imaging method in diagnosing, staging and during follow up. Conventional PET/CT with 18F-labelled fluorodeoxyglucose (18F-FDG) has its limitations and therefore has a secondary role in imaging pancreatic cancer patients. These conventional imaging methods are good in detecting primary tumors and distant metastasis but poor in detecting local lymph node metastasis. A new PET tracer, fibroblast activation protein inhibitor (FAPI), targets FAP, a protein overexpressed in cancer-associated fibroblasts. It presents a potential new PET imagining tool. The objective of this prospective diagnostic study is to evaluate the diagnostic efficacy of 18F-FAPI-74 PET/CT in patients with PC. The aim is to evaluate the sensitivity and specificity of 18F-FAPI-74 in detection of local lymph node metastasis and distant metastasis in patient level in patients with PC in primary staging and when suspected recurrence. 100 patients with PC are enrolled on whom PET/CT studies are performed with the novel 18F-FAPI-74 tracer. The data will be collected between 2024-2026.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• Suspected primary or recurrent pancreatic cancer

• Subjects must be male or female aged 18-85 years.

• WHO performance score 0-2.

• Subjects must be able and willing to give written informed consent and to comply with the requirements of this study protocol.

Locations
Other Locations
Finland
Turku PET Centre, Turku University Hospital
RECRUITING
Turku
Contact Information
Primary
Saila Kauhanen, docent
saila.kauhanen@utu.fi
+358503017010
Time Frame
Start Date: 2024-10-09
Estimated Completion Date: 2026-10
Participants
Target number of participants: 100
Treatments
Experimental: Staging
Related Therapeutic Areas
Sponsors
Leads: Turku University Hospital

This content was sourced from clinicaltrials.gov