Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma (VAPOR2)

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The investigators are developing a non-invasive breath test to help us detect pancreatic cancer earlier. The test detects small molecules called volatile organic compounds that are made by pancreatic cancers. Pancreatic cancer is a rare disease but patients are often diagnosed at a late stage because their symptoms are the same as those of many common illnesses. This makes it hard for doctors to know which patients need to be tested for pancreatic cancer. If the investigators find pancreatic cancer at a late stage, it reduces the number of treatment choices for patients. Our test could be offered to patients who are experiencing vague symptoms, which might be caused either by pancreatic cancer or a common illness. This test could help doctors to identify which of those patients may have pancreatic cancer, and ensure they get referred for specialised pancreatic cancer tests. The investigators hope that this will allow us to diagnose pancreatic cancer earlier, increasing treatment choices for patients and improving survival from pancreatic cancer. The investigators have previously conducted a study (VAPOR1) which collected breath samples from people with and without pancreatic cancer. When the investigators analysed these samples, they found that there is a difference in the volatile organic compounds breathed out by people who have pancreatic cancer compared to those that do not. The investigators used these 'markers' to develop a breath test to diagnose pancreatic cancer. In VAPOR2, the investigators will study our breath test in a much larger group of patients who have been referred for further investigations for potential underlying pancreatic cancer to see how accurately it can pick up the small percentage of people who have pancreatic cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult participants ≥ 18 years old

• Referral from primary care according to the urgent suspected cancer referral guidelines for potential underlying pancreatic cancer, or referral directly to a pancreatic cancer multidisciplinary team meeting

Locations
Other Locations
United Kingdom
Imperial College Healthcare NHS Trust
RECRUITING
London
Contact Information
Primary
Emma Austin
vapor@imperial.ac.uk
+44 (0)20 7594 3653
Backup
Caoimhe Walsh, MBBS, MRCS
vapor@imperial.ac.uk
+44 (0)20 7594 3653
Time Frame
Start Date: 2025-10-21
Estimated Completion Date: 2028-08-01
Participants
Target number of participants: 6079
Treatments
VAPOR2 Participants
6079 participants above the age of 18 years with potential underlying pancreatic cancer referred from primary care according to urgent suspected cancer referral guidelines or referred directly to a pancreatic cancer multidisciplinary team meeting.
Sponsors
Collaborators: Newcastle-upon-Tyne Hospitals NHS Trust, Royal Free Hospital NHS Foundation Trust, Imperial College Healthcare NHS Trust, Dorset County Hospital NHS Foundation Trust, Liverpool University Hospitals NHS Foundation Trust, Buckinghamshire Healthcare NHS Trust, University Hospital Southampton NHS Foundation Trust, Sherwood Forest Hospitals NHS Foundation Trust, Pancreatic Cancer UK
Leads: Imperial College London

This content was sourced from clinicaltrials.gov