Comparison of the Effectiveness of Paracetamol With Ibuprofen or Paracetamol With Metamizole in Treating Pain in Acute Pancreatitis in Children: a Randomized Trial
The aim of the study is to assess the effectiveness and tolerance of pain treatment in AP in children using intravenous paracetamol in combination with ibuprofen or paracetamol in combination with metamizole. The study is prospective, interventional, and randomized.
• diagnosis of AP according to the INSPPIRE mentioned above criteria,
• age from 3 to 18 years of age,
• abdominal pain on admission assessed on the Numerical Rating Scale (NRS) or FLACC \>= 4 points,
• no analgesic treatment before enrolment in the study OR the last dose of analgesic drug (paracetamol, ibuprofen, metamizole) taken ≥ 6 hours before enrolment for examination,
• consent of legal guardians and the child (in the case of patients ≥16 years of age) to participate in the study.