Ultrasound and Gene-Guided Microwave Ablation Versus Surgery for Low-Risk Papillary Thyroid Carcinoma: a Prospective Observational Cohort Study.

Status: Recruiting

Location: See location...

Intervention Type: Procedure

Study Type: Observational

SUMMARY

This study aims to investigate the efficacy and prognosis of ultrasound-guided and gene-based microwave ablation (MWA) versus surgical treatment in patients with low-risk papillary thyroid carcinoma (PTC). By analyzing genetic testing results, the study explores the impact of genetic mutations on treatment selection for low-risk patients, providing more precise molecular biological evidence for treatment choices and prognosis evaluation of thyroid cancer. This prospective study collects clinical data from patients diagnosed with PTC at Sun Yat-sen Memorial Hospital of Sun Yat-sen University between January 2022 and November 2024, who underwent genetic testing prior to treatment, and assesses efficacy and complications through long-term follow-up.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Maximum Age: 70

Healthy Volunteers: f

View:

• PTC confirmed by fine-needle aspiration (FNA);

• Confirmed low-risk mutation types by next-generation sequencing (NGS) before surgery;

• No severe functional diseases, such as heart failure, severe respiratory diseases, or renal failure;

• Availability of complete follow-up data.

Locations

Other Locations

China

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

RECRUITING

Guangzhou

Contact Information

Primary

Miaoyun Long, MD

longmy@mail.sysu.edu.cn

86-34070602

Backup

Yuxin Shen, MBBS

shenyx53@mail2.sysu.edu.cn

86-15083138712

Time Frame

Start Date: 2022-01-01

Estimated Completion Date: 2025-03-04

Participants

Target number of participants: 201

Treatments

Ablation Group

Patients in this group received ablation therapy for low-risk papillary thyroid carcinoma. The ablation method used was microwave ablation (MWA), with ablation performed under ultrasound guidance. Patients were informed of the potential risks and benefits of ablation, and follow-ups were conducted at regular intervals using thyroid ultrasound and contrast-enhanced ultrasound to evaluate treatment efficacy and disease progression.

Surgery Group

Patients in this group underwent surgical treatment for low-risk papillary thyroid carcinoma. The surgery performed was partial or total thyroidectomy, based on the patient's condition and preferences. Patients were informed of the risks, including potential complications such as hypothyroidism, recurrent laryngeal nerve injury, and hypoparathyroidism. Follow-ups were conducted using thyroid ultrasound and clinical assessments to monitor for recurrence and evaluate postoperative recovery.

Related Therapeutic Areas

Thyroid Cancer

Papillary Thyroid Cancer

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Ultrasound and Gene-Guided Microwave Ablation Versus Surgery for Low-Risk Papillary Thyroid Carcinoma: a Prospective Observational Cohort Study.

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