Parathyroid AdenomaSymptoms, Doctors, Treatments, Advances & More
Learn About Parathyroid Adenoma
A parathyroid adenoma is a noncancerous (benign) tumor of the parathyroid glands. The parathyroid glands are located in the neck, near or attached to the back side of the thyroid gland.
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The parathyroid glands in the neck help regulate calcium absorption, use, and removal by the body. They do this by producing parathyroid hormone, or PTH. PTH helps regulate calcium, phosphorus, and vitamin D levels in the blood and bone. It is important for healthy bones.
Parathyroid adenomas are common. Most parathyroid adenomas do not have an identified cause. Sometimes a genetic problem is the cause. This is more common if the diagnosis is made when you are young.
Parathyroid adenomas may occur in people without a family history of the disease, or as part of 3 inherited syndromes:
- Multiple endocrine neoplasia (MEN) I
- Multiple endocrine neoplasia (MEN) IIA
- Isolated familial hyperparathyroidism
In people with an inherited syndrome, a changed (variant) gene is passed down through the family. You only need to get the gene from one parent to develop the condition.
- In MEN I, problems in the parathyroid glands occur, as well as tumors in the pituitary gland and pancreas.
- In MEN IIA, overactivity of the parathyroid glands occurs, along with tumors in the adrenal or thyroid gland.
Conditions that stimulate the parathyroid glands to get bigger can also cause an adenoma. These include:
- Genetic disorders
- Taking the medicine lithium
- Chronic kidney disease
Women over age 60 have the highest risk for developing this condition. Radiation to the head or neck also increases the risk.
Many people have no symptoms. The condition is often discovered when blood tests are done for another medical reason.
Parathyroid adenomas are the most common cause of hyperparathyroidism (overactive parathyroid glands), which leads to an increased blood calcium level. Symptoms may include any of the following:
- Confusion
- Constipation
- Lack of energy (lethargy)
- Muscle pain
- Nausea or decreased appetite
- Urinating more often at night
- Weak bones or fractures
Surgery is the most common treatment, and it often cures the condition. But, some people choose to only have regular checkups with their health care provider if the condition is mild.
To help improve the condition, your provider may ask you to stop taking calcium and vitamin D supplements. Women who have gone through menopause may want to discuss treatment with estrogen or other medicines to prevent bone loss.
The Johns Hopkins Hospital
William Simonds is an Endocrinologist in Baltimore, Maryland. Dr. Simonds is rated as an Elite provider by MediFind in the treatment of Parathyroid Adenoma. His top areas of expertise are Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia, Parathyroid Adenoma, Parathyroidectomy, and Thymectomy.
Maria Brandi practices in Florence, Italy. Brandi is rated as an Elite expert by MediFind in the treatment of Parathyroid Adenoma. Their top areas of expertise are Osteoporosis, Hypophosphatemia, Postmenopausal Osteoporosis, Parathyroidectomy, and Hormone Replacement Therapy (HRT).
Endocrine Surgery And Oncology Clinic
Dr. Julie Ann Sosa is an endocrine surgeon who specializes in thyroid cancer. She also has expertise in treating adults and children for a variety of benign and malignant endocrine conditions of the thyroid, parathyroid and adrenal glands. She chairs the UCSF Department of Surgery. Sosa's research focuses on developing treatments for advanced thyroid cancer and understanding environmental factors that can raise a person's risk for the disease. She also has published extensively on predictors of optimal patient outcomes following a variety of cancer-based procedures. Sosa earned her medical degree at Johns Hopkins University School of Medicine, where she also completed the Halsted residency in general surgery and served as chief resident. She completed a fellowship in clinical research with the Robert Wood Johnson Foundation at Johns Hopkins, where she was also assistant chief of service and an instructor. She has a master's degree in human sciences from the University of Oxford. Prior to joining UCSF, she was chief of endocrine surgery at Duke University, and held leadership positions at the Duke Cancer Institute and Duke Clinical Research Institute. Sosa is a fellow of the American College of Surgeons. She is the elected editor-in-chief of the World Journal of Surgery, and had previous positions as deputy editor of JAMA Surgery and associate editor of the Journal of Surgical Research. She serves on the editorial boards of seven medical journals, including the Annals of Surgery, Surgery, Annals of Surgical Oncology, Endocrine and International Journal of Endocrine Oncology. She serves on the boards of the Society of Surgical Oncology, International Thyroid Oncology Group, Association for Academic Surgery Foundation and American Thyroid Association, where she is also treasurer. She is the Leon Goldman, MD Distinguished Professor of Surgery at UCSF. Sosa was born in Montréal and raised in upstate New York. Dr. Sosa is rated as an Elite provider by MediFind in the treatment of Parathyroid Adenoma. Her top areas of expertise are Thyroid Cancer, Parathyroid Hyperplasia, Papillary Thyroid Cancer, Thyroidectomy, and Parathyroidectomy.
When treated, outlook is generally good.
Osteoporosis and the increased risk for bone fractures is the most common concern.
Other complications are less common, but may include:
- Calcium deposits in the kidneys that can reduce kidney function (nephrocalcinosis)
- Softened, weak areas in the bones (osteitis fibrosa)
Complications from surgery include:
- Damage to a nerve that controls your voice
- Damage to the parathyroid glands, which causes hypoparathyroidism (lack of enough parathyroid hormone) and low calcium level
Contact your provider if you have symptoms of this condition.
Background: * Endocrine neoplasms (tumors) are among the fastest growing tumors in incidence in the United States. Furthermore, it is often difficult to distinguish between benign or malignant tumors in cancers of the thyroid, parathyroid, adrenal gland, and pancreas. More research is needed to improve detection and treatment options for patients who develop these kinds of cancer. * Researchers are interested...
Background: Parathyroid disorders are very common in the general population and include disorders of parathyroid excess, deficiency, or defects in parathyroid hormone (PTH) signaling. PTH, the main secretory product of parathyroid glands is responsible for regulation of calcium-phosphate homeostasis.
Published Date: May 20, 2024
Published By: Sandeep K. Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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Thakker RV. The parathyroid glands, hypercalcemia, and hypocalcemia. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 227.
Walker MD, Bilezikian JP. Primary hyperparathyroidism. In: Robertson RP, ed. DeGroot's Endocrinology. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 54.