Enhancing rTMS Effects Through a State-Dependent Approach - An Intervention for Bradykinesia in Parkinson's Disease
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study investigates the use of patterned repetitive transcranial magnetic stimulation (prTMS) as an intervention for bradykinesia in Parkinson's Disease (PD). More specifically, the study aims to determine whether prTMS over the supplementary motor area (SMA) can reduce severity of bradykinesia in PD patients. This approach may open for more targeted and effective treatment of bradykinesia in PD.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Above 18 years of age. Clinically established or probable Parkinson's Disease (PD), according to the Movement Disorder Society.
• Clinical Diagnostic Criteria for PD. Stable antiparkinsonian medicine for at least four weeks. Signed informed consent.
Locations
Other Locations
Denmark
DRCMR
RECRUITING
Hvidovre
Contact Information
Primary
Ann-Charlot Rughaven, M.Sc.
ann-charlot.rughaven@regionh.dk
+4521123531
Time Frame
Start Date: 2025-12-16
Estimated Completion Date: 2027-05-01
Participants
Target number of participants: 27
Treatments
Active_comparator: Active patterned repetitive transcranial magnetic stimulation (prTMS) before a movement
Real stimulation with four pulses at the frequency of 200 Hertz (Hz) repeating a 0.2Hz will be delivered on the supplementary motor area (SMA) using the active side of the coil for 30 min. Every burst will be given 100 milliseconds (ms) before a movement.
Experimental: Active patterned repetitive transcranial magnetic stimulation (prTMS) between a movement
Real stimulation with four pulses at the frequency of 200 hertz (Hz) repeating a 0.2Hz will be delivered on the supplementary motor area (SMA) using the active side of the coil for 30 min. Every burst will be given between movements.
Sham_comparator: Sham patterned repetitive transcranial magnetic stimulation (prTMS) before a movement
Sham stimulation with four pulses at the frequency of 200 hertz (Hz) repeating a 0.2Hz will be delivered on the supplementary motor area (SMA) using the non-active side of the coil for 30 min. Every burst will be 100 milliseconds (ms) before a movement.
Related Therapeutic Areas
Sponsors
Leads: Danish Research Centre for Magnetic Resonance