Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?
Who is this study for? Adult patients with patent foramen ovale and intrapulmonary arteriovenous anastomosis and pulmonary hypertension
What treatments are being studied? Sildenafil
Status: Completed
Location: See location...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
In summary, the investigators propose to study elite Croatian breath-hold and SCUBA divers. The investigators will quantify breath-hold hypoxia- and SCUBA diving-induced pulmonary hypertension and right heart function to investigate the relationships between PFO and IPAVA blood flow. The investigators will use a placebo-controlled intervention (sildenafil) to reduce pulmonary arterial pressure in these subjects to examine the impact of the change in pressure (or absence of change) on the relationships determined above.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:
• Reside in geographic location near Split, Croatia
• Elite breath hold divers
• Experienced SCUBA divers
Locations
United States
Oregon
Cardiorespiratory and Pulmonary Physiology Lab
Eugene
Time Frame
Start Date: 2019-07-01
Completion Date: 2023-07-31
Participants
Target number of participants: 82
Treatments
Active_comparator: Sildenafil administration
Administration of 50mg sildenafil one time, one hour prior to measurements
Placebo_comparator: Placebo administration
Administration of 50mg placebo one time, one hour prior to measurements
Related Therapeutic Areas
Sponsors
Leads: University of Oregon