Pellagra is a disease that occurs when a person does not get enough niacin (one of the B complex vitamins) or tryptophan (an amino acid).
Vitamin B3 deficiency; Deficiency - niacin; Nicotinic acid deficiency
Pellagra is caused by having too little niacin or tryptophan in the diet. It can also occur if the body fails to absorb these nutrients.
Pellagra may also develop due to:
The disease is common in parts of the world (certain parts of Africa) where people have a lot of untreated corn in their diet. Corn is a poor source of tryptophan, and niacin in corn is tightly bound to other components of the grain. Niacin is released from corn if soaked in limewater overnight. This method is used to cook tortillas in Central America where pellagra is rare.
Symptoms of pellagra include:
The goal of treatment is to increase your body's niacin level. You will be prescribed niacin supplements. You may also need to take other supplements. Follow your provider's instructions exactly on how much and how often to take the supplements.
Symptoms due to the pellagra, such as skin sores, will be treated.
If you have conditions that are causing the pellagra, these will also be treated.
People often do well after taking niacin.
Left untreated, pellagra can result in nerve damage, particularly in the brain. Skin sores may become infected.
Call your provider if you have any symptoms of pellagra.
Pellagra can be prevented by following a well-balanced diet.
Get treated for health problems that may cause pellagra.
Elia M, Lanham-New SA. Nutrition. In: Kumar P, Clark M, eds. Kumar and Clarke's Clinical Medicine. 9th ed. Philadelphia, PA: Elsevier; 2017:chap 10.
Meisenberg G, Simmons WH. Micronutrients. In: Meisenberg G, Simmons WH, eds. Principles of Medical Biochemistry. 4th ed. Philadelphia, PA: Elsevier; 2017:chap 31.
So YT. Deficiency diseases of the nervous system. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016:chap 85.
There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.
There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.