Confounding Factors of Chronic Endometritis in Women With Reproductive Failure
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
The aim of the study is to investigate the confounding factors of chronic endometritis and therapeutic benefits of antibodies targeting plasma cells in women with reproductive failure.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 20
Maximum Age: 45
Healthy Volunteers: f
View:
• Age 20-45 years;
• Women with a history of 2 or more consecutive miscarriages before 24 weeks of gestation12; or
• Women who failed to conceive after unprotected intercourse for one year; or
• Women who failed failure to achieve a clinical pregnancy after two consecutive cycles of IVF, ICSI or frozen embryo replacement cycles where the cumulative number of transferred embryos is no less than four for day-2 embryos and no less than 2 for day-5 embryos (blastocysts), with all embryos being of good quality.
Locations
Other Locations
Hong Kong Special Administrative Region
The Chinese University of Hong Kong
RECRUITING
Hong Kong
Contact Information
Primary
Stacey Wong, BSc
staceywong@cuhk.edu.hk
35051764
Backup
JacquelinePui Wah Chung, MBBS
jacquelinechung@cuhk.edu.hk
35051764
Time Frame
Start Date: 2023-01-26
Estimated Completion Date: 2028-01-31
Participants
Target number of participants: 720
Treatments
Observational group
Patients have 2 or more miscarriage or repeated implantation failure (RIF), or infertile women would be invited to do endometrial sampling (ES) procedure. The ES will be conducted randomly or when women undergo hysteroscopy or obtained precisely 7 days after LH surge. It will be obtained using a Pipelle sampler as an outpatient procedure.
Related Therapeutic Areas
Sponsors
Leads: Chinese University of Hong Kong